Oletha DeVane is an accomplished multi-media artist who explores political, social and cultural interpretations in a variety of mediums.

She has been featured in numerous select galleries and museums, such as the Corcoran Gallery of Art, the Art Museum of the Americas in Washington, D.C., the Museum of the Bible in New York, the Dixon Gallery in Tennessee, the James E. Lewis Museum at Morgan State University and is in collections of several institutions such as the Sheppard Pratt Hospital, Hyatt Regency and Hilton Hotels in Baltimore, Johns Hopkins University Homewood Museum, Loyola University and other numerous private collections. The Reginald F. Lewis Museum of African American History and Culture commissioned DeVane to create a permanent video installation documenting Maryland's history of lynching. As part of an NEA grant, DeVane collaborated on a body of work at Pyramid Atlantic with the "Girls of Baltimore". A Sondheim semi finalist, her works was exhibited in Meyerhoff Gallery at Maryland Institute College of Art. She is a recent recipient of the Ruby Grant to do a mosaic project in Camp Coq, Haiti and 2017 Art Matters Award.

She was one of the first African-American artists invited as an Artist-in-Residence to the United Arab Emirates and was an Artist in Residence in the baroque city of Lecce with the Bau Institute in Italy. An artist and educator, she has taught art classes in South Africa, South America, and Thailand. DeVane chaired the Visual Arts in the upper school at McDonogh School, teaches art and is the Director of the Tuttle Gallery at McDonogh School. She is Co-Chair on a committee for the McDonogh History House/Museum and Slave Memorial project. She was the recipient of the Rollins Luetkemeyer Chair in 2007 for Distinguished Teaching.